Bryce Buddle

Principal Scientist

E: bryce.buddle@agresearch.co.nz

Qualifications

BVSc, Massey, New Zealand

Dip Microbiol., Otago, New Zealand

PhD, Blacksburg-Virginia, USA

Diplomate of the Amercian College of Veterinary Microbiologists

FRSNZ

Research interests & activities

Development and evaluation of vaccines and diagnostic tests for control of infectious diseases of animals, with a particular emphasis on bovine tuberculosis and Johne’s disease.

Awards

Hutton Medal, Royal Society of New Zealand, contribution to animal science (2008)

Watson award for outstanding contribution to immunology (2006)

Centenary award from British Veterinary Association (1996)

Vernon Willey award for research into sheep production (1988)

Publications

Buddle, B.M., de Lisle, G.W., Griffin, J.F.T., Hutchings, S.A. 2015. Epidemiology, diagnostics, and management of bovine tuberculosis in domestic cattle and deer in New Zealand in the face of a wildlife reservoir. New Zealand Veterinary Journal doi.org/10.1080/00480169.2014.929518.

Parlane, N.A., Shu, D., Subharat, S., Wedlock, D.N., Rehm, B.H.A., de Lisle, G.W., Buddle, B.M. 2014. Revaccination of cattle with Bacille Calmette-Guérin two years after first vaccination when immunity has waned, boosted protection against challenge with Mycobacterium bovis. PLOS ONE, 9: e106519.

Chen, S., Parlane, N.A., Lee, J., Wedlock, D.N., Buddle, B.M., Rehm, B.H.A. 2014. New skin test for detection of bovine tuberculosis based on antigen-displaying polymer inclusions produced by recombinant Escherichia coli. Applied Environmental Microbiology 80: 2526-2535.

Wedlock, D.N., Buddle, B.M., Williamson, J., Lacy-Hulbert, J., Turner, S-A., Subharat, S., Heiser, A. 2014. Dairy cows produce cytokine and cytotoxic T cell responses following vaccination with an antigenic fraction from Streptococcus uberis. Veterinary Immunology Immunopathology 160: 51-60.

Shu, D., Heiser, A., Wedlock, D.N., Luo, D., de Lisle, G.W., Buddle, B.M. 2014. Comparison of gene expression of immune mediators in cattle lung and pulmonary lymph node granulomas from cattle experimentally infected with Mycobacterium bovis. Veterinary. Immunology Immunopathology 160: 81-89.

Buddle, B.M., Parlane, N.A., Wedlock, D.N., Heiser, A. 2013. Overview of vaccination trials for control of tuberculosis in cattle, wildlife and humans. Transboundary Emerging Diseases 60 (Suppl.1), 136-146.

Subharat, S., Shu, D., Wedlock, D.N., Price-Carter, M., de Lisle, G.W., Luo, D., Collins, D.M., Buddle, B.M. 2012. Immune responses associated with progression and control of infection in calves experimentally challenged with Mycobacterium avium subsp. paratuberculosis. Veterinary Immunology Immunopathology 149: 225-36.

Parlane, N.A., Grage, K., Mifune, J., Basaraba, R.J., Wedlock, D.N., Rehm, B.H.A., Buddle, B.M. 2012. Vaccines displaying mycobacterial proteins on biopolyester beads stimulate cellular immunity and induce protection against tuberculosis. Clinical Vaccine Immunology 19: 37-44.

Buddle, B.M., Wilson, T., Aldwell, F.E., de Lisle, G.W., Vordermeier, H.M., Hewinson, R.G., Wedlock, D.N. 2011. Low oral BCG doses fail to protect cattle against an experimental challenge with Mycobacterium bovis. Tuberculosis 91: 400-405.

Tompkins D.M., Ramsey D.S.L, Cross M.L., Aldwell, F.E., de Lisle, G.W., Buddle, B.M. 2009. Oral vaccination reduces the incidence of bovine tuberculosis in a free-living wildlife species. Proceedings of the Royal Society. B. Biological Sciences 276: 2987-2995.